The external work-pressure time integral relationships and the afterload dependence of Frank-Starling mechanism.

@article{Sela2009TheEW,
  title={The external work-pressure time integral relationships and the afterload dependence of Frank-Starling mechanism.},
  author={Gali Sela and Amir Landesberg},
  journal={Journal of molecular and cellular cardiology},
  year={2009},
  volume={47 4},
  pages={
          544-51
        }
}
The mechanisms underlying the Frank-Starling Law of the heart are elusive and the prevalent notion suggests that it is afterload independent. However, isolated fiber studies reveal that the afterload determines cardiac function through cross-bridge dependent mechanisms. The study explores the roles of the afterload, in situ. The LV was exposed by left-thoracotomy in adult sheep (72.6+/-8.2 kg, n=8). Pressure transducers were inserted into the LV and aorta, a flowmeter was placed around the… CONTINUE READING