The aim of this work is to evaluate the extent of usage of the System for BMSI and the profile of users, as well as to compare the results with data from the previous period. Information were gathered from the request forms for searching databases, filled out by the users. In the 4-year period (1990-1993) 1640 searches were carried out, 870 for women and 770 for men. There were 1301 users from Belgrade and 339 from outside Belgrade. Compared with the previous period (1988-1989), the usage of biomedical databases increased remarkably (58%) and played a major role in the research of scientific workers in Serbia, especially considering serious deficit of contemporary periodicals.