The extent of neurofibrillary pathology in perforant pathway neurons is the key determinant of dementia in the very old

@article{GarcaSierra2000TheEO,
  title={The extent of neurofibrillary pathology in perforant pathway neurons is the key determinant of dementia in the very old},
  author={Francisco Garc{\'i}a-Sierra and J.-J. Hauw and Charles Duyckaerts and Claude M. Wischik and Sof{\'i}a D{\'i}az-Cintra and Ra{\'u}l D{\'a}vila Mena},
  journal={Acta Neuropathologica},
  year={2000},
  volume={100},
  pages={29-35}
}
Abstract Neurofibrillary pathology as found in Alzheimer’s disease (AD) is also found in the normal elderly, suggesting that these changes may be part of the aging process. In this study, we assessed the densities and distribution of structures recognized by the monoclonal antibody (mAb) to phosphorylated tau (AT8) in the hippocampal formation and medial temporal isocortex of 19 centenarians. Of these, 4 cases were demented and 15 non-demented. AT8 immunoreactivity correlated with the global… CONTINUE READING
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Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996

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