The extent of matrix damage and chondrocyte death in mechanically traumatized articular cartilage explants depends on rate of loading.

@article{Ewers2001TheEO,
  title={The extent of matrix damage and chondrocyte death in mechanically traumatized articular cartilage explants depends on rate of loading.},
  author={Benjamin J Ewers and D Dvoracek-Driksna and Michael W. Orth and Roger C. Haut},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2001},
  volume={19 5},
  pages={779-84}
}
Mechanical loads can lead to matrix damage and chondrocyte death in articular cartilage. This damage has been implicated in the pathogenesis of secondary osteoarthritis. Studies on cartilage explants with the attachment of underlying bone at high rates of loading have documented cell death adjacent to surface lesions. On the other hand, studies involving… CONTINUE READING