The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins

@inproceedings{Tsang2014TheEO,
  title={The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins},
  author={Ellen Tsang and Izumi Miyabe and Ismail Iraqui and Jiping Zheng and Sarah A. E. Lambert and Antony M Carr},
  booktitle={Journal of cell science},
  year={2014}
}
Genetic instability, a hallmark of cancer, can occur when the replication machinery encounters a barrier. The intra-S-phase checkpoint maintains stalled replication forks in a replication-competent configuration by phosphorylating replisome components and DNA repair proteins to prevent forks from catastrophically collapsing. Here, we report a novel function of the core Schizosaccharomyces pombe checkpoint sensor kinase, Rad3 (an ATR orthologue), that is independent of Chk1 and Cds1 (a CHK2… CONTINUE READING
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