The extent of cytokine induction in peripheral nerve lesions depends on the mode of injury and NMDA receptor signaling

@article{Kleinschnitz2004TheEO,
  title={The extent of cytokine induction in peripheral nerve lesions depends on the mode of injury and NMDA receptor signaling},
  author={Christoph Kleinschnitz and James Brinkhoff and Marek Zelenka and Clemens Sommer and Guido Stoll},
  journal={Journal of Neuroimmunology},
  year={2004},
  volume={149},
  pages={77-83}
}
We compared cytokine and chemokine induction in mice after sciatic nerve crush and chronic constriction injury (CCI) by quantitative reverse transcriptase polymerase chain reaction. In both nerve lesion paradigms, transcripts for tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, IL-10, and monocyte chemoattractant protein-1 (MCP-1) were significantly increased in degenerating nerve stumps already at day 1, with a greater magnitude and longer duration in CCI. NMDA receptor… CONTINUE READING

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