The extent of amotosalen photodegradation during photochemical treatment of platelet components correlates with the level of pathogen inactivation.

@article{Liu2011TheEO,
  title={The extent of amotosalen photodegradation during photochemical treatment of platelet components correlates with the level of pathogen inactivation.},
  author={Weiqun Liu and George D. Cimino and Laurence Corash and Lily Lin},
  journal={Transfusion},
  year={2011},
  volume={51 1},
  pages={52-61}
}
BACKGROUND Amotosalen plus ultraviolet A (UVA) light inactivates a broad range of bacteria, viruses, protozoa, and leukocytes in platelet (PLT) and plasma components. Upon UVA illumination a small fraction of amotosalen reacts with the nucleic acid of contaminating pathogens and residual white blood cells and the remaining fraction undergoes photodegradation into defined photoproducts. The levels of amotosalen and photoproducts can be accurately quantified. STUDY DESIGN AND METHODS This study… CONTINUE READING

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