The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid beta in mice.

@article{Alkam2008TheEN,
  title={The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid beta in mice.},
  author={Tursun Alkam and Atsumi Nitta and Hiroyuki Mizoguchi and Akio Itoh and Rina Murai and Taku Nagai and Kiyofumi Yamada and Toshitaka Nabeshima},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={327 1},
  pages={137-47}
}
Tyrosine nitration of proteins at an extensive level is widely associated with the cognitive pathology induced by amyloid beta peptide (Abeta). However, the precise identity and explicit consequences of protein nitration have scarcely been addressed. In this study, we examined the detectable nitration of proteins in the hippocampus of mice with cognitive impairment (day 5) induced by the i.c.v. injection of Abeta(25-35) (day 0). The intensity of the nitration of proteins was inversely… CONTINUE READING

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