The expression pattern of TIR8 is conserved among vertebrates.

  title={The expression pattern of TIR8 is conserved among vertebrates.},
  author={Federica Riva and Nadia Polentarutti and Giulia Tribbioli and Alberto Mantovani and Cecilia Garlanda and Lauretta Turin},
  journal={Veterinary immunology and immunopathology},
  volume={131 1-2},
IL-1R/TLRs play an important role in the inflammatory responses. Their signaling pathway is tightly regulated to keep inflammation under control. The regulation involves both extracellular and intracellular mechanisms. TIR8, also known as SIGIRR (Single Immunoglobulin IL-1R-Related molecule), is an orphan receptor belonging to the IL-1R/TLRs super-family. Recent studies suggest its role in modulating the inflammatory response in the gastrointestinal tract in mice, acting as an IL-1 receptor… CONTINUE READING

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