The expression of two P-glycoprotein (pgp) genes in transgenic Caenorhabditis elegans is confined to intestinal cells.

Abstract

P-glycoproteins can cause multidrug resistance in mammalian tumor cells by active extrusion of cytotoxic drugs. The natural function of these evolutionarily conserved, membrane-bound ATP binding transport proteins is unknown. In mammals, P-glycoproteins are abundantly present in organs associated with the digestive tract. We have studied the tissue-specific… (More)

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@article{Lincke1993TheEO, title={The expression of two P-glycoprotein (pgp) genes in transgenic Caenorhabditis elegans is confined to intestinal cells.}, author={Carsten Lincke and Annegien Broeks and Inge The and Ronald H. A Plasterk and Piet Borst}, journal={The EMBO journal}, year={1993}, volume={12 4}, pages={1615-20} }