The expression of transforming growth factor-beta1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma.

@article{Saito1999TheEO,
  title={The expression of transforming growth factor-beta1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma.},
  author={Hidetugu Saito and Shunichi Tsujitani and Sohich Oka and Akira Kondo and Masahide Ikeguchi and Michio Maeta and Nobuaki Kaibara},
  journal={Cancer},
  year={1999},
  volume={86 8},
  pages={1455-62}
}
BACKGROUND Transforming growth factors beta (TGFs beta) are involved in a variety of important cellular functions, including cell growth and differentiation, adhesion, migration, extracellular matrix formation, and immune function. Moreover, it has been reported that TGFs beta are correlated with angiogenesis. However, the role of TGF-beta as an angiogenic factor in gastric carcinoma is still unclear. METHODS TGF-beta1 expression was determined in 101 patients with gastric carcinoma by… CONTINUE READING

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However , the role of TGF - beta as an angiogenic factor in gastric carcinoma is still unclear .
TGF - beta1 expression was determined in 101 patients with gastric carcinoma by immunohistochemical procedures , and this expression was compared in the current study with both the expression of vascular endothelial growth factor ( VEGF ) , which is thought to be the most potent angiogenic factor , and microvessel density , to evaluate the effect of TGF - beta1 on the angiogenesis of gastric carcinoma tissues .
TGF - beta1 expression was determined in 101 patients with gastric carcinoma by immunohistochemical procedures , and this expression was compared in the current study with both the expression of vascular endothelial growth factor ( VEGF ) , which is thought to be the most potent angiogenic factor , and microvessel density , to evaluate the effect of TGF - beta1 on the angiogenesis of gastric carcinoma tissues .
However , the role of TGF - beta as an angiogenic factor in gastric carcinoma is still unclear .
TGF - beta1 expression was determined in 101 patients with gastric carcinoma by immunohistochemical procedures , and this expression was compared in the current study with both the expression of vascular endothelial growth factor ( VEGF ) , which is thought to be the most potent angiogenic factor , and microvessel density , to evaluate the effect of TGF - beta1 on the angiogenesis of gastric carcinoma tissues .
TGF - beta1 expression was determined in 101 patients with gastric carcinoma by immunohistochemical procedures , and this expression was compared in the current study with both the expression of vascular endothelial growth factor ( VEGF ) , which is thought to be the most potent angiogenic factor , and microvessel density , to evaluate the effect of TGF - beta1 on the angiogenesis of gastric carcinoma tissues .
These results suggest that TGF - beta1 might be associated with tumor progression by indirectly stimulating angiogenesis through the up - regulation of VEGF expression in gastric carcinoma .
The expression of transforming growth factor - beta1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma .
TGF - beta1 expression was determined in 101 patients with gastric carcinoma by immunohistochemical procedures , and this expression was compared in the current study with both the expression of vascular endothelial growth factor ( VEGF ) , which is thought to be the most potent angiogenic factor , and microvessel density , to evaluate the effect of TGF - beta1 on the angiogenesis of gastric carcinoma tissues .
TGF - beta1 expression was determined in 101 patients with gastric carcinoma by immunohistochemical procedures , and this expression was compared in the current study with both the expression of vascular endothelial growth factor ( VEGF ) , which is thought to be the most potent angiogenic factor , and microvessel density , to evaluate the effect of TGF - beta1 on the angiogenesis of gastric carcinoma tissues .
The expression of transforming growth factor - beta1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma .
TGF - beta1 expression was determined in 101 patients with gastric carcinoma by immunohistochemical procedures , and this expression was compared in the current study with both the expression of vascular endothelial growth factor ( VEGF ) , which is thought to be the most potent angiogenic factor , and microvessel density , to evaluate the effect of TGF - beta1 on the angiogenesis of gastric carcinoma tissues .
TGF - beta1 expression was determined in 101 patients with gastric carcinoma by immunohistochemical procedures , and this expression was compared in the current study with both the expression of vascular endothelial growth factor ( VEGF ) , which is thought to be the most potent angiogenic factor , and microvessel density , to evaluate the effect of TGF - beta1 on the angiogenesis of gastric carcinoma tissues .
TGF - beta1 expression was determined in 101 patients with gastric carcinoma by immunohistochemical procedures , and this expression was compared in the current study with both the expression of vascular endothelial growth factor ( VEGF ) , which is thought to be the most potent angiogenic factor , and microvessel density , to evaluate the effect of TGF - beta1 on the angiogenesis of gastric carcinoma tissues .
VEGF protein, humanGene product plays role in biological processAngiogenic Process
TGF - beta1 expression was determined in 101 patients with gastric carcinoma by immunohistochemical procedures , and this expression was compared in the current study with both the expression of vascular endothelial growth factor ( VEGF ) , which is thought to be the most potent angiogenic factor , and microvessel density , to evaluate the effect of TGF - beta1 on the angiogenesis of gastric carcinoma tissues .
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