The expression of transforming growth factor-alpha in cirrhosis, dysplastic nodules, and hepatocellular carcinoma: an immunohistochemical study of 70 cases.

@article{Yeh2007TheEO,
  title={The expression of transforming growth factor-alpha in cirrhosis, dysplastic nodules, and hepatocellular carcinoma: an immunohistochemical study of 70 cases.},
  author={Matthew M Yeh and Anne M. Larson and Jean S. Campbell and Nelson Fausto and Stephen J. Rulyak and Paul E. Swanson},
  journal={The American journal of surgical pathology},
  year={2007},
  volume={31 5},
  pages={681-9}
}
The emergence of hepatocellular carcinoma (HCC) is thought to be a stepwise process, with high-grade dysplastic nodules (HGDN) representing premalignant lesions arising in a background of cirrhosis. Earlier studies have revealed altered expression of transforming growth factor-alpha (TGF-alpha) (a mitogen capable of inducing hepatocarcinogenesis in mice) in HCC and its surrounding parenchyma. DNA topoisomerase II-alpha (Topo II-alpha) is a nuclear protein targeted by several chemotherapeutic… CONTINUE READING
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