The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia.

@article{Kang2012TheEO,
  title={The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia.},
  author={Rui Kang and Tara Jean Loux and Daolin Tang and Nicole E. Schapiro and Philip J. Vernon and Kristen M. Livesey and Alyssa M. Krasinskas and Michael T Lotze and Herbert J. Zeh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 18},
  pages={7031-6}
}
Pancreatic cancer is an almost uniformly lethal disease, characterized by late diagnosis, early metastasis, resistance to chemotherapy, and early mutation of the Kras oncogene. Here we show that the receptor for advanced glycation endproducts (RAGE) is required for the activation of interleukin 6 (IL-6)-mediated mitochondrial signal transducers and activators of transcription 3 (STAT3) signaling in pancreatic carcinogenesis. RAGE expression correlates with elevated levels of autophagy in… CONTINUE READING

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