The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells.

@article{Stein1985TheEO,
  title={The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells.},
  author={Harald Stein and David Y. Mason and Johannes Gerdes and N. O'connor and James S. Wainscoat and Gorm Pallesen and Kevin C. Gatter and Brunangelo Falini and Georges Delsol and Hilmar Lemke},
  journal={Blood},
  year={1985},
  volume={66 4},
  pages={
          848-58
        }
}
Ki-1 is a monoclonal antibody (raised against a Hodgkin's disease-derived cell line) that, in biopsy tissue affected by Hodgkin's disease, reacts selectively with Reed-Sternberg cells. The expression of Ki-1 antigen has been analyzed by immunocytochemical techniques in a wide range of human tissue and cell samples, including fetal tissue, malignant lymphomas (290 cases), and mitogen- and virus-transformed peripheral blood lymphocytes. The antigen was detectable on a variable proportion of cells… Expand
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