The expression of proto-oncogene eIF4E in laryngeal squamous cell carcinoma.

@article{Liang2003TheEO,
  title={The expression of proto-oncogene eIF4E in laryngeal squamous cell carcinoma.},
  author={Zhou Liang and Tao Lei and Zheng Lu-ying and Gao Yu-ping},
  journal={The Laryngoscope},
  year={2003},
  volume={113 7},
  pages={
          1238-43
        }
}
OBJECTIVES/HYPOTHESIS The translation initiation factor eukaryotic initiation factor 4E (eIF4E) binds to the cap of messenger RNA in the first step of messenger RNA recruitment. Overexpression of eIF4E results in the upregulation of specific angiogenic factor basic fibroblast growth factor (bFGF). The study aims to demonstrate that the overexpression of eIF4E could facilitate recognizing initiation start sites for the translation of bFGF and play an important role in the tumorigenesis of… CONTINUE READING