The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse.

@article{Masuyama2001TheEO,
  title={The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse.},
  author={Hisashi Masuyama and Yuji Hiramatsu and Yasushi Mizutani and Hideshi Inoshita and Takafumi Kudo},
  journal={Molecular and cellular endocrinology},
  year={2001},
  volume={172 1-2},
  pages={47-56}
}
Recently, pregnane X receptor (PXR) has been described to mediate the genomic effects of several steroid hormones, such as progesterone (P), glucocorticoid (Dex), pregnenolone (Preg), and xenobiotics through the cytochrome P-450 3A gene family (CYP3A), which are monooxygenases, responsible for the oxidative metabolism of some endogenous substrates and xenobiotics. In the present study, we used a transient transfection reporter gene expression assay of COS-7 cells to demonstrate that P, Dex and… CONTINUE READING