The expression of p18INK4 and p27kip1 cyclin-dependent kinase inhibitors is regulated differently during human B cell differentiation.

@article{Schrantz2000TheEO,
  title={The expression of p18INK4 and p27kip1 cyclin-dependent kinase inhibitors is regulated differently during human B cell differentiation.},
  author={Nicolas Schrantz and Georges Edouard Beney and M T Auffredou and Marie Françoise Bourgeade and G{\'e}rald Leca and Aim{\'e} V{\'a}zquez},
  journal={Journal of immunology},
  year={2000},
  volume={165 8},
  pages={
          4346-52
        }
}
Cell cycle progression is under the control of cyclin-dependent kinases (cdks), the activity of which is dependent on the expression of specific cdk inhibitors. In this paper we report that the two cdk inhibitors, p27(Kip1) and p18(INK4c), are differently expressed and control different steps of human B lymphocyte activation. Resting B cells contain large amounts of p27(Kip1) and no p18(INK4c). In vitro stimulation by Staphylococcus aureus Cowan 1 strain or CD40 ligand associated with IL-10 and… CONTINUE READING

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