The expression of nicotinic acetylcholine receptors by PC12 cells treated with NGF.

@article{Rogers1992TheEO,
  title={The expression of nicotinic acetylcholine receptors by PC12 cells treated with NGF.},
  author={Scott W. Rogers and Allan Mandelzys and Evan S Deneris and E. Cooper and Stephen J Heinemann},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1992},
  volume={12 12},
  pages={4611-23}
}
The expression of neuronal nicotinic ACh receptors (nAChRs) and the subunits that compose these receptors by PC12 cells exposed to NGF has been studied. The analysis of total RNA reveals that the neuronal nAChR subunits alpha 3, alpha S, beta 2, beta 3, and beta 4, but not alpha 2 and alpha 4, are expressed in our PC12 cells. Within 48 hr of adding NGF to cultures, the RNA corresponding to alpha 3, alpha 5, beta 3, and beta 4 is decreased, but the beta 2 RNA increases for up to 6 d after NGF… CONTINUE READING

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