The expression of nicotinic acetylcholine receptors by PC12 cells treated with NGF.

  title={The expression of nicotinic acetylcholine receptors by PC12 cells treated with NGF.},
  author={Scott W. Rogers and Allan Mandelzys and Evan S Deneris and E. Cooper and Stephen J Heinemann},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={12 12},
The expression of neuronal nicotinic ACh receptors (nAChRs) and the subunits that compose these receptors by PC12 cells exposed to NGF has been studied. The analysis of total RNA reveals that the neuronal nAChR subunits alpha 3, alpha S, beta 2, beta 3, and beta 4, but not alpha 2 and alpha 4, are expressed in our PC12 cells. Within 48 hr of adding NGF to cultures, the RNA corresponding to alpha 3, alpha 5, beta 3, and beta 4 is decreased, but the beta 2 RNA increases for up to 6 d after NGF… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 46 extracted citations


Publications referenced by this paper.
Showing 1-10 of 61 references

c + , ( Ye , and p 4 : three members of the rat neuronal nicotinic acetylcholine receptor - related gene family form a gene cluster

  • J Boulter, A O’Shea-Greenfield, +8 authors J Patrick
  • J Biol Chem
  • 1990
Highly Influential
6 Excerpts

ical and functional diversity of neuronal nicotinic acetylcholine receptors

  • ES Deneris, J Connolly, +5 authors S Heinemann
  • Trends Phannacol
  • 1988
Highly Influential
5 Excerpts

PC1 2 pheochromocytoma cell in neurobiology research

  • LA Greene, AS Tischler
  • Adv Cell Neurobiol
  • 1982
Highly Influential
4 Excerpts

Effects of eanalionic satellite cells and NGF on the expression of nicotinic ac & yLholine currents by rat sensory neurons

  • A Mandelzvs, Cooner E f
  • J Neurophysiol
  • 1992

nicotinic acetylcholine receptors is increased by a novel subunit : 6 ,

  • CM Plores, SW Rogers, LA Pabreeza, BB Wolfe, KJ Kellar
  • 1992

Methodologies for the culture and experimental use of the PC1 2 rat pheochromocytoma cell line

  • LA Greene, MM Sobeth, KK Teng
  • (Banker G, Goslin K,
  • 1991

proportion of functional acetylcholine receptors on chick ciliary ganglion neurons

  • RL Papke, S Heinemann
  • Proc Nat1 Acad Sci USA
  • 1991

Similar Papers

Loading similar papers…