The expression of methiopropamine-induced locomotor sensitization requires dopamine D2, but not D1, receptor activation in the rat

  title={The expression of methiopropamine-induced locomotor sensitization requires dopamine D2, but not D1, receptor activation in the rat},
  author={Hyung Shin Yoon and Wen Ting Cai and Young Hun Lee and Kyung Tae Park and Yong Sup Lee and Jeong-Hoon Kim},
  journal={Behavioural Brain Research},
Methiopropamine (MPA) is a structural analog to methamphetamine and is categorized as a novel psychoactive substance that needs to be controlled. However, no study has been performed to determine whether MPA actually develops an addiction-like behavior similar to those arising from other psychomotor stimulants. Thus, we attempted to determine whether MPA produces locomotor sensitization in a manner similar to amphetamine. In the first experiment, rats were pre-exposed to either saline or one of… Expand
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  • P. Vezina
  • Chemistry, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996
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