The expression of low molecular weight protein tyrosine phosphatase is up-regulated in 1,2-dimethylhydrazine-induced colon tumours in rats.

@article{Marzocchini2008TheEO,
  title={The expression of low molecular weight protein tyrosine phosphatase is up-regulated in 1,2-dimethylhydrazine-induced colon tumours in rats.},
  author={Riccardo Marzocchini and Francesca Malentacchi and Massimiliano Biagini and Domenico Cirelli and Cristina Luceri and Giovanna Caderni and Giovanni Raugei},
  journal={International journal of cancer},
  year={2008},
  volume={122 7},
  pages={1675-8}
}
Recent studies have assessed the role of low molecular weight protein tyrosine phosphatase (LMW-PTP) in cell transformation and tumour onset and progression, observing a significant increase in the expression of LMW-PTP mRNA and protein in human breast, colon, bladder and kidney tumour samples. Moreover, its enhanced expression is generally prognostic of a more aggressive cancer. To better understand the role of this protein during colon carcinogenesis and to study whether its overexpression is… CONTINUE READING
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