The expression of genes of the steroid-thyroid hormone receptor superfamily in central nervous system tumors.

Abstract

We studied the expression of ten genes (encoding the receptors for glucocorticoid, mineralocorticoid, progesterone, androgen, estrogen, thyroid, retinoid acid, vitamin D) belonging to the steroid-thyroid hormone receptor superfamily (STRS) in 12 neuroepithelial tumors, 12 meningiomas and 2 human glioblastoma cell lines. Our method, based on the polymerase chain reaction, allowed the simultaneous amplification of cDNAs of the STRS genes. On average, 7 STRS genes were simultaneously expressed in each sample. Our study indicates that many STRS gene are commonly co-expressed in human CNS tumors. The importance of our results for the ongoing and proposed hormonal treatment trials is discussed.

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@article{Magrassi1993TheEO, title={The expression of genes of the steroid-thyroid hormone receptor superfamily in central nervous system tumors.}, author={Lorenzo Magrassi and Giorgio Butti and Enrico Maria Silini and Francesco Bono and Pietro Paoletti and Gabriele Milanesi}, journal={Anticancer research}, year={1993}, volume={13 4}, pages={859-66} }