The expression of decorin in human ovarian tumors.

  title={The expression of decorin in human ovarian tumors.},
  author={Michael A Nash and Michael T. Deavers and R. S. Freedman},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={8 6},
PURPOSE The purpose of this study was to examine ovarian cancer cells for the expression of decorin, a proteoglycan component of the cell matrix that can inhibit cancer cell growth. EXPERIMENTAL DESIGN Cultured ovarian cancer cells and surgically excised tumors were examined by immunohistochemistry and Western blot analysis for decorin expression. Reverse transcription-polymerase chain reaction analysis was used to analyze cultured cells for decorin transcripts. RESULTS We detected decorin… CONTINUE READING