The expression of brain cyclooxygenase-2 is down-regulated in the cytosolic phospholipase A2 knockout mouse.

@article{Bosetti2003TheEO,
  title={The expression of brain cyclooxygenase-2 is down-regulated in the cytosolic phospholipase A2 knockout mouse.},
  author={Francesca Bosetti and Gayani R Weerasinghe},
  journal={Journal of neurochemistry},
  year={2003},
  volume={87 6},
  pages={1471-7}
}
We examined brain phospholipase A2 (PLA2) activity and the expression of enzymes metabolizing arachidonic acid (AA) in cytosolic PLA2 knockout () mice to see if other brain PLA2 can compensate for the absence of cPLA2 alpha and if cPLA2 couples with specific downstream enzymes in the eicosanoid biosynthetic pathway. We found that the rate of formation of prostaglandin E2 (PGE2), an index of net cyclooxygenase (COX) activity, was decreased by 62% in the compared with the control mouse brain. The… CONTINUE READING