The expression of a metallothionein-ovine growth hormone fusion gene in transgenic mice does not impair fertility but results in pathological lesions in the liver.

@article{Orian1989TheEO,
  title={The expression of a metallothionein-ovine growth hormone fusion gene in transgenic mice does not impair fertility but results in pathological lesions in the liver.},
  author={J. M. Orian and Catherine S N Lee and Lawrence M. Weiss and Malcolm R. Brandon},
  journal={Endocrinology},
  year={1989},
  volume={124 1},
  pages={455-63}
}
The physiological effects of high serum levels of ovine GH (oGH) were studied in three generations of transgenic mice carrying a metallothionein 1-(MT)oGH fusion gene. Livers of mice expressing oGH were enlarged, irrespective of the level of serum oGH detected. In mice expressing high levels of oGH, direct measurements of hepatocytes in liver sections revealed that cell and nuclear size were abnormally large. Hepatocytes of different transgenic mice varied from 1.4-2.2 times normal size and… CONTINUE READING

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