The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice.

@article{Karasuyama1994TheEO,
  title={The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice.},
  author={Hajime Karasuyama and Antonius G. Rolink and Yoichi Shinkai and Faith Young and Frederick W Alt and Fritz Georg Melchers},
  journal={Cell},
  year={1994},
  volume={77 1},
  pages={133-43}
}
Precursor B (pre-B) cells in bone marrow of normal and B cell-deficient mutant mice were analyzed for the expression of Vpre-B/lambda 5 surrogate light chain (SL). The surface expression of SL is confined to the early stages (pro-B and pre-B-I) of pre-B cell development and becomes undetectable once mu heavy chain (microH) is produced. The cell-cycle analysis revealed that cytoplasmic microH+ large cells (large pre-B-II), approximately 30% of which coexpressed SL in the cytoplasm, were most… CONTINUE READING

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