The expression of TNF alpha by human muscle. Relationship to insulin resistance.

@article{Saghizadeh1996TheEO,
  title={The expression of TNF alpha by human muscle. Relationship to insulin resistance.},
  author={Mehrnoosh Saghizadeh and John M. Ong and W Timothy Garvey and Robert R. Henry and Philip A Kern},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 4},
  pages={1111-6}
}
TNFalpha is orverexpressed in the adipose tissue of obese rodents and humans, and is associated with insulin resistance. To more closely link TNF expression with whole body insulin action, we examined the expression of TNF by muscle, which is responsible for the majority of glucose uptake in vivo. Using RT-PCR, TNF was detected in human heart, in skeletal muscle from humans and rats, and in cultured human myocytes. Using competitive RT-PCR, TNF was quantitated in the muscle biopsy specimens… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 234 extracted citations

Skeletal muscle inflammation and insulin resistance in obesity.

The Journal of clinical investigation • 2017
View 18 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…