The expression of RET and its multiple splice forms in developing human kidney

@article{Ivanchuk1997TheEO,
  title={The expression of RET and its multiple splice forms in developing human kidney},
  author={Stacey M Ivanchuk and Charis Eng and Webster K Cavenee and Lois M Mulligan},
  journal={Oncogene},
  year={1997},
  volume={14},
  pages={1811-1818}
}
A series of inductive events between two different cell groups, the ureteric bud epithelium and metanephric mesenchyme, gives rise to the functional mammalian kidney. These reciprocal inductive interactions involve a number of molecules, one of which is the RET receptor tyrosine kinase. The phenotype of mice lacking functional RET includes kidney agenesis or severe dysgenesis, indicating a requirement for RET in kidney organogenesis. To investigate RET expression in human kidney development, we… CONTINUE READING

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