The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome.

@article{Loomes1999TheEO,
  title={The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome.},
  author={Kathleen M. Loomes and Lara A. Underkoffler and Justin Morabito and S L Gottlieb and David A. Piccoli and Nancy B. Spinner and Harold Scott Baldwin and Rebecca J. Oakey},
  journal={Human molecular genetics},
  year={1999},
  volume={8 13},
  pages={2443-9}
}
The establishment of the cardiovascular system represents an early, critical event essential for normal embryonic development, and defects in cardiovascular development are a frequent cause of both in utero and neonatal demise. Congenital cardio-vascular malformations, the most frequent birth defect, can occur as isolated events, but are frequently presented clinically within the context of a constellation of defects that involve multiple organs and that define a specific syndrome. In addition… CONTINUE READING
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