• Corpus ID: 54707576

The expression levels of platelet adhesive receptors in PRP derived platelet concentrates during storage

@article{Fatemeh2016TheEL,
  title={The expression levels of platelet adhesive receptors in PRP derived platelet concentrates during storage},
  author={Nassaji Fatemeh and Ghasemzadeh Mehran and Pirmohammad Jamaat Zeynab and Hosseini Ehteramolsadat},
  journal={Tehran University Medical Journal TUMS Publications},
  year={2016},
  volume={74},
  pages={16-24}
}
Background: Major platelet adhesive receptors that contribute significantly to thrombus formation include platelet receptor glycoprotein Ibα (GPIbα) of the GPIb-IX-V complex and platelet glycoprotein VI (GPVI). GPIbα plays a crucial role in platelet tethering to sub-endothelial matrix, which initiates thrombus formation at arterial shear rates, whereas GPVI is critically involved in platelets firm adhesion to the site of injury regardless of shear condition. During storage, platelets experience… 
2 Citations
Reactive oxygen species generation as marker of platelet activation in PRP derived platelet concentrates during storage: brief report
TLDR
This study showed significant increases in ROS generation during the storage of platelet concentrates correlated with the increments of P-selectin expression as an important marker of platelets activation, suggesting that the analysis of ROS generation can also be considered a marker of Platelet activation during storage.
Reactive Oxygen Species Generated by CD45- Cells Distinct from Leukocyte Population in Platelet Concentrates Is Correlated with the Expression and Release of Platelet Activation Markers during Storage
TLDR
ROS generations were significantly correlated with ectodomain shedding of these pro-inflammatory molecules and confirmed increasing levels of intracellular ROS generation in both platelets (CD45-) and platelet-leukocyte aggregates ( CD45+) during PC storage.

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