The expression level of ecto-NTP diphosphohydrolase1/CD39 modulates exocytotic and ischemic release of neurotransmitters in a cellular model of sympathetic neurons.

@article{Corti2011TheEL,
  title={The expression level of ecto-NTP diphosphohydrolase1/CD39 modulates exocytotic and ischemic release of neurotransmitters in a cellular model of sympathetic neurons.},
  author={Federico Corti and Kim E. Olson and Aaron J. Marcus and Roberto Levi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={337 2},
  pages={524-32}
}
Once released, norepinephrine is removed from cardiac synapses via reuptake into sympathetic nerves, whereas transmitter ATP is catabolized by ecto-NTP diphosphohydrolase 1 (E-NTPDase1)/CD39, an ecto-ATPase. Because ATP is known to modulate neurotransmitter release at prejunctional sites, we questioned whether this action may be ultimately controlled by the expression of E-NTPDase1/CD39 at sympathetic nerve terminals. Accordingly, we silenced E-NTPDase1/CD39 expression in nerve growth factor… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Pharmacological profiles of cloned mammalian P2Y-receptor subtypes

  • I von Kügelgen
  • Pharmacol Ther 110:415–432
  • 2006
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…