The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development.
@article{Pauken2000TheEA,
title={The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development.},
author={Christine M Pauken and David G. Capco},
journal={Developmental biology},
year={2000},
volume={223 2},
pages={
411-21
}
}Signaling events mediate many processes that act during embryogenesis to initiate the program of early development. Within the cell many of these changes are mediated through the activation or inactivation of kinases and phosphatases. Protein kinase C (PKC) is one kinase that has been shown to be involved in at least two developmental transitions during early development, fertilization and embryonic compaction. PKC is a family of kinases whose various isotypes have differing requirements for…
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References
SHOWING 1-10 OF 40 REFERENCES
Expression and cell membrane localization of catenins during mouse preimplantation development
- BiologyDevelopmental dynamics : an official publication of the American Association of Anatomists
- 1996
The results suggest that the components of the E‐cadherin‐catenin complex derived from both maternal and zygotic gene activity are increasingly accumulated and stored in a nonfunctional form during early cleavage stages and are ready to be used for compaction and the formation of the trophectodermal cell layer.
Involvement of protein kinase C in nuclear migration during compaction and the mechanism of the migration: analyses in two-cell mouse embryos.
- BiologyDevelopmental biology
- 1993
The results obtained with PKC activators/inhibitor, colchicine, and calmodulin antagonists suggest that nuclear migration is mediated by increases in PKC activity, requires intact microtubules, and is accompanied by PKC-dependent increases in cell-cell adhesion.
Regulation of cell adhesion during embryonic compaction of mammalian embryos: Roles for PKC and β‐catenin
- BiologyMolecular reproduction and development
- 1999
Investigation of the mechanisms that regulate embryonic compaction, the first cell adhesion event in early mammalian development, finds that β‐catenin became phosphorylated on serine/threonine residues both during induced compaction and normal development.
Activation of protein kinase C triggers premature compaction in the four-cell stage mouse embryo.
- BiologyDevelopmental biology
- 1990
Expression of catenins during mouse embryonic development and in adult tissues.
- BiologyCell adhesion and communication
- 1995
It is reported that catenins are widely expressed but in varying amounts in embryos and adult tissues, and the expression of all three catenin is most prominent in the adult heart muscle and in epithelia of all developmental stages.
Activation of protein kinase C after fertilization is required for remodeling the mouse egg into the zygote
- BiologyMolecular reproduction and development
- 1997
It is concluded that protein kinase C plays an integral role in directing the transformation from egg to embryo.
PKC ‐ A pivotal regulator of early development
- BiologyBioEssays : news and reviews in molecular, cellular and developmental biology
- 1997
Technical advancements discussed in this review have permitted a better understanding of the actions of protein kinase C, which can choreograph the cell's remodeling events in both space and time.
Characterization of conventional protein kinase C (PKC) isotype expression during F9 teratocarcinoma differentiation. Overexpression of PKC alpha alters the expression of some differentiation-dependent genes.
- BiologyThe Journal of biological chemistry
- 1994
Expression of protein kinase C gene family members is temporally and spatially regulated during neural development in vitro.
- BiologyEuropean journal of cell biology
- 1998
Expression patterns of novel genes during mouse preimplantation embryogenesis
- BiologyMolecular reproduction and development
- 1994
The temporal patterns of expression of genes expressed following zygotic gene activation and preimplantation development were analyzed by a reverse transcription‐polymerase chain reaction (RT‐PCR) assay developed to measure relative levels of mRNAs.







