The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development.

@article{Pauken2000TheEA,
  title={The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development.},
  author={Christine M Pauken and David G. Capco},
  journal={Developmental biology},
  year={2000},
  volume={223 2},
  pages={
          411-21
        }
}
Signaling events mediate many processes that act during embryogenesis to initiate the program of early development. Within the cell many of these changes are mediated through the activation or inactivation of kinases and phosphatases. Protein kinase C (PKC) is one kinase that has been shown to be involved in at least two developmental transitions during early development, fertilization and embryonic compaction. PKC is a family of kinases whose various isotypes have differing requirements for… 

Figures and Tables from this paper

Involvement of the PKC family in regulation of early development
TLDR
Evidence exists to indicate involvement of PKC isotypes during sperm capacitation and the acrosome reaction, during resumption of meiosis in the oocytes, regulating the spindle organization in meiosis I and II, at fertilization, and at the plasma membranes of blastomeres at the time of embryonic compaction.
Expression profile of protein kinase C isozymes in preimplantation mouse development.
TLDR
There was a transient increase in the nuclear concentration of several isozymes at the early four-cell stage, suggesting that some of the PKC isoz enzymes might be involved in regulation of nuclear organization and function in the early mouse embryo.
The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development.
TLDR
Observations provide novel insights into PRKCD mRNA expression profiles in bovine embryos and provide evidence forPRKCD-dependent regulation of embryonic development, gene expression and post-hatching events.
Molecular and biochemical regulation of early mammalian development.
  • D. Capco
  • Biology
    International review of cytology
  • 2001
PKC signaling at fertilization in mammalian eggs.
  • G. Halet
  • Biology
    Biochimica et biophysica acta
  • 2004
Alterations in the protein kinase C signaling activated by a parthenogenetic agent in oocytes from reproductively old mice
TLDR
Findings provide evidence that aging affects the correct storage and activation of some PKCs, functional components of the machinery involved in oocyte activation, and suggest that these changes may negatively influence the activation competence of old oocytes.
Expression of cell adhesion molecules during human preimplantation embryo development.
TLDR
The amplification of representative cDNAs from morphologically and developmentally normal, individual human embryos at all stages from pronucleate to blastocyst is described and a role for alpha v beta 5 and alpha 6 beta 1 integrin dimers in the human embryo at implantation is proposed.
Effect of protein phosphatase inhibitors on the development of mouse embryos: protein phosphorylation is involved in the E-cadherin distribution in mouse two-cell embryos.
TLDR
The distribution pattern of E-cadherin protein was altered by the addition of calyculin A from a scattered pattern throughout the embryos to a localized pattern at the cell-cell boundary region, which strongly suggest that the distribution of E.cadhersin protein is regulated by protein phosphorylation and/or dephosphorylation.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 40 REFERENCES
Expression and cell membrane localization of catenins during mouse preimplantation development
TLDR
The results suggest that the components of the E‐cadherin‐catenin complex derived from both maternal and zygotic gene activity are increasingly accumulated and stored in a nonfunctional form during early cleavage stages and are ready to be used for compaction and the formation of the trophectodermal cell layer.
Involvement of protein kinase C in nuclear migration during compaction and the mechanism of the migration: analyses in two-cell mouse embryos.
TLDR
The results obtained with PKC activators/inhibitor, colchicine, and calmodulin antagonists suggest that nuclear migration is mediated by increases in PKC activity, requires intact microtubules, and is accompanied by PKC-dependent increases in cell-cell adhesion.
Regulation of cell adhesion during embryonic compaction of mammalian embryos: Roles for PKC and β‐catenin
TLDR
Investigation of the mechanisms that regulate embryonic compaction, the first cell adhesion event in early mammalian development, finds that β‐catenin became phosphorylated on serine/threonine residues both during induced compaction and normal development.
Expression of catenins during mouse embryonic development and in adult tissues.
TLDR
It is reported that catenins are widely expressed but in varying amounts in embryos and adult tissues, and the expression of all three catenin is most prominent in the adult heart muscle and in epithelia of all developmental stages.
Activation of protein kinase C after fertilization is required for remodeling the mouse egg into the zygote
TLDR
It is concluded that protein kinase C plays an integral role in directing the transformation from egg to embryo.
PKC ‐ A pivotal regulator of early development
TLDR
Technical advancements discussed in this review have permitted a better understanding of the actions of protein kinase C, which can choreograph the cell's remodeling events in both space and time.
Expression patterns of novel genes during mouse preimplantation embryogenesis
TLDR
The temporal patterns of expression of genes expressed following zygotic gene activation and preimplantation development were analyzed by a reverse transcription‐polymerase chain reaction (RT‐PCR) assay developed to measure relative levels of mRNAs.
...
1
2
3
4
...