The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase

@article{Amin1995TheEA,
  title={The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase},
  author={Ashok R. Amin and Paul E. Di Cesare and Paresh Vyas and Mukundan G. Attur and Edith E. Tzeng and Timothy R Billiar and Steven A. Stuchin and Steven B. Abramson},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={182},
  pages={2097 - 2102}
}
Classically, osteoarthritis (OA) has been considered a noninflammatory disease. However, the detection of selected inflammatory mediators in osteoarthritic fluid, in the absence of significant inflammatory cell infiltrate, is increasingly appreciated. We sought to identify the inflammatory component in human OA-affected cartilage that may be involved in… CONTINUE READING