Corpus ID: 83064467

The expression and regulation of membranetype matrix metalloproteinases (MT-MMPS) in prostate cancer

@inproceedings{Palliyaguru2005TheEA,
  title={The expression and regulation of membranetype matrix metalloproteinases (MT-MMPS) in prostate cancer},
  author={Tishila Palliyaguru},
  year={2005}
}
Prostate cancer (PCa) represents the most frequently diagnosed cancer and the second leading cause of cancer death in males. Initial development and progression of the disease is mainly regulated by androgens. However, the pathology of the disease may progress to a loss of hormone dependence, resulting in rapid growth and a metastatic phenotype. Invasion and metastasis of tumour cells results from the degradation of the basement membrane (BM) and extracellular matrix (ECM). The… Expand

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TLDR
Investigation of the expression of MMPs and endogenous inhibitors in two parent epithelial prostate cancer cell lines and sublines of increasing invasive/metastatic potential found MMP-1, M MP-13 and TIMP-1 was higher in the more aggressive sublines and may be implicated in invasive/ metastatic ability. Expand
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