Corpus ID: 83064467

The expression and regulation of membranetype matrix metalloproteinases (MT-MMPS) in prostate cancer

  title={The expression and regulation of membranetype matrix metalloproteinases (MT-MMPS) in prostate cancer},
  author={Tishila Palliyaguru},
Prostate cancer (PCa) represents the most frequently diagnosed cancer and the second leading cause of cancer death in males. Initial development and progression of the disease is mainly regulated by androgens. However, the pathology of the disease may progress to a loss of hormone dependence, resulting in rapid growth and a metastatic phenotype. Invasion and metastasis of tumour cells results from the degradation of the basement membrane (BM) and extracellular matrix (ECM). The… Expand


Characterization of expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in prostate cancer cell lines
Investigation of the expression of MMPs and endogenous inhibitors in two parent epithelial prostate cancer cell lines and sublines of increasing invasive/metastatic potential found MMP-1, M MP-13 and TIMP-1 was higher in the more aggressive sublines and may be implicated in invasive/ metastatic ability. Expand
Membrane-type metalloproteinases in tumor invasion.
In vivo and in vitro data confirm the important role of MT-MMPs in tumor invasion and highlight a cooperation between tumor and stromal cells for the production of these enzymes. Expand
Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) on prostate cancer cell lines.
Results suggest that MT1-MMP is indeed the tumor-specific activator of proMMP-2 in androgen-independent prostate cancer cells and plays an important role in the invasive properties of prostate cancer Cells. Expand
[Significance of membrane type-1 matrix metalloproteinase expression in breast cancer].
MT1-MMP protein and mRNA expression in human breast cancers had positive correlation with the stage, the tumor size and lymph node metastasis and can be a predictor for the ability of breast cancer invasion and metastasis. Expand
Upregulated expression of human membrane type-5 matrix metalloproteinase in kidneys from diabetic patients.
The results provide the first evidence of the expression of a MT-MMP in diabetes and suggest a novel role for MT5-M MP in the pathogenesis of renal tubular atrophy and end-stage renal disease. Expand
Membrane type 1-matrix metalloproteinase (MT1-MMP) targeted antitumor agents
2453 Matrix metalloproteinase (MMP) activity is required for tumour growth and metastasis. This study assessed the expression of membrane-type MMP1 (MT1-MMP) in human Non Small Cell Lung CancerExpand
The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis
The role of MMPs and their inhibitors in tumor invasion, angiogenesis and metastasis with special emphasis on the gelatinases, M MP-2 and MMP-9 are discussed. Expand
The metastasis-associated metalloproteinase stromelysin-3 is induced by transforming growth factor-beta in osteoblasts and fibroblasts.
Stimulation of stromelysin-3 expression by TGF-beta in fibroblasts and osteoblasts could play a role in the metastasis of breast cancer cells and their homing and survival in bone. Expand
Presence of high levels of MT1‐MMP protein in fibroblastic cells of human invasive carcinomas
MT1‐MMP protein was present in all invasive carcinomas tested, and it was almost exclusively located to the stromal cells and not to cancer cells as previously reported, suggesting that MMP2 activation might be a peri‐fibroblastic event. Expand
Membrane-type matrix metalloproteinases (MT-MMPs) in cell invasion.
MT1-MMP and its family may play a central role in the cell surface localization and activation of progelatinase A and via this mechanism, tumor cells use exogenous progelasinase A to mediate the proteolysis associated with invasion and metastasis. Expand