The experimental neuropathy in rats caused by p-bromophenylacetylurea.


In 1960, Diezel and Quadbeck reported that parabromophenylacetylurea, when given to rats by mouth in a single dose of 200 mg/kg, caused paralysis of the hind limbs after an interval of 10-14 days. Of 12 halogenated derivatives of phenylacetylurea that these authors studied only this compound had this effect. When they examined these animals histologically… (More)


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