The experimental neuropathy in rats caused by p-bromophenylacetylurea.

  title={The experimental neuropathy in rats caused by p-bromophenylacetylurea.},
  author={John B. Cavanagh and Frank C. Chen and M H Kyu and Alan Ridley},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  volume={31 5},
In 1960, Diezel and Quadbeck reported that parabromophenylacetylurea, when given to rats by mouth in a single dose of 200 mg/kg, caused paralysis of the hind limbs after an interval of 10-14 days. Of 12 halogenated derivatives of phenylacetylurea that these authors studied only this compound had this effect. When they examined these animals histologically up to one month after poisoning, they found degeneration of peripheral nerve fibres and changes in the anterior horn cells and in the white… CONTINUE READING