The experimental design and data interpretation in “Unexpected mutations after CRISPR–Cas9 editing in vivo” by Schaefer et al. are insufficient to support the conclusions drawn by the authors

  • Published 2017


The recent correspondence to the Editor of Nature Methods by Schaefer et. al. has garnered significant attention since its publication as a result of its strong conclusions contradicting numerous publications in the field using similar analytical approaches and methods. The authors suggest that the CRISPR-Cas9 system is highly mutagenic in genomic regions… (More)

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