The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis

@article{Pawlik2003TheEO,
  title={The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis},
  author={Andrzej PawlikA. Pawlik and Lidia Ostanek and Iwona Brzosko and Marek Brzosko and Marek Masiuk and Bogusław Machaliński and Barbara Gawrońska-Szklarz},
  journal={Arthritis Research & Therapy},
  year={2003},
  volume={5},
  pages={R210 - R213}
}
Clonal expansion of CD4+CD28- T cells is a characteristic finding in patients with rheumatoid arthritis (RA). Expanded CD4+ clonotypes are present in the peripheral blood, infiltrate into the joints, and persist for years. CD4+CD28- T cells are oligoclonal lymphocytes that are rare in healthy individuals but are found in high percentages in patients with chronic inflammatory diseases. The size of the peripheral blood CD4+CD28- T-cell compartment was determined in 42 patients with RA and 24… CONTINUE READING
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