The expansion and maintenance of antigen-selected CD8(+) T cell clones.

@article{Fearon2007TheEA,
  title={The expansion and maintenance of antigen-selected CD8(+) T cell clones.},
  author={Douglas T Fearon},
  journal={Advances in immunology},
  year={2007},
  volume={96},
  pages={103-39}
}
The biological purpose of the mature, postthymic CD8(+) T cell is to respond to microbial antigens with a developmental program of clonal expansion and concomitant differentiation leading to effector cells (T(EFF)) that provide antimicrobial defense. Because many microbial infections persist into a chronic phase, this antigen-stimulated developmental program must be capable of continually generating T(EFF), perhaps for the lifetime of the individual. This chapter proposes that the ability of a… CONTINUE READING

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