The expanding universe of T-cell subsets: Th1, Th2 and more.

  title={The expanding universe of T-cell subsets: Th1, Th2 and more.},
  author={Tim R. Mosmann and Subash Sad},
  journal={Immunology today},
  volume={17 3},
Since their discovery nearly ten years ago, T helper 1 (Th1) and Th2 subsets have been implicated in the regulation of many immune responses. In this article, Tim Mosmann and Subash Sad discuss the increasing number of T-cell subsets defined by cytokine patterns; the differentiation pathways of CD4+ and CD8+ T cells; the contribution of other cell types to these patterns; and the cytokine interactions during infection and pregnancy. 
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