The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease.

  title={The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease.},
  author={Inge Seim and Carina M. Walpole and Laura de Amorim and Peter F Josh and Adrian C. Herington and Lisa Chopin},
  journal={Molecular and cellular endocrinology},
  volume={340 1},
Obestatin is a 23 amino acid, ghrelin gene-derived peptide hormone produced in the stomach and a range of other tissues throughout the body. While it was initially reported that obestatin opposed the actions of ghrelin with regards to appetite and food intake, it is now clear that obestatin is not an endogenous ghrelin antagonist, but it is a multi-functional peptide hormone in its own right. In this review we will discuss the controversies associated with the discovery of obestatin and explore… CONTINUE READING

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Meta - analysis of the relationship between obestatin and ghrelin levels and the ghrelin / obestatin ratio with respect to obesity

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Expression analysis of key somatotropic axis and liporegulatory genes in ghrelin - and obestatin - infused dairy cows

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