The expanding role of prodrugs in contemporary drug design and development

@article{Rautio2018TheER,
  title={The expanding role of prodrugs in contemporary drug design and development},
  author={Jarkko Rautio and Nicholas A. Meanwell and Li Di and Michael J. Hageman},
  journal={Nature Reviews Drug Discovery},
  year={2018},
  volume={17},
  pages={559-587}
}
Prodrugs are molecules with little or no pharmacological activity that are converted to the active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two. Prodrugs have evolved from being serendipitously discovered or used as a salvage effort to being intentionally designed. Such efforts can avoid drug development challenges that limit formulation options or result in unacceptable biopharmaceutical or pharmacokinetic performance, or poor targeting. In the past 10… 
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