The expanding role of NLRs in antiviral immunity.

  title={The expanding role of NLRs in antiviral immunity.},
  author={Christopher R. Lupfer and Thirumala-Devi Kanneganti},
  journal={Immunological reviews},
  volume={255 1},
Nucleotide oligomerization and binding domain (NOD)-like receptors (NLRs) are a major constituent of the cytosolic innate immune-sensing machinery and participate in a wide array of pathways including nuclear factor κB (NF-κB), mitogen-activated protein kinase (MAPK), inflammasome, and type I interferon (IFN) signaling. NLRs have known roles in autoimmune, autoinflammatory, and infectious diseases. With respect to virus infection, NLRP3 is the most extensively studied NLR, including mechanisms… CONTINUE READING