The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function

@article{Coyle2001TheEB,
  title={The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function},
  author={Anthony J Coyle and José Carlos Gutiérrez-Ramos},
  journal={Nature Immunology},
  year={2001},
  volume={2},
  pages={203-209}
}
Upon encounter with specific antigen, naïve T helper precursor (THP) cells become activated. This event is regulated not only by engagement of the T cell receptor (TCR) with peptide presented in the context of major histocompatibility complex (MHC) class II molecules but by a number of costimulatory signals. CD28 engagement by B7-1 and B7-2 on resting THP cells provides a critical signal for initial cell cycle progression, interleukin 2 production and clonal expansion. However, largely as a… 
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