The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer.

@article{Sveen2012TheEB,
  title={The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer.},
  author={Anita Sveen and Anne Cathrine Bakken and Trude Holmeide Agesen and Guro E Lind and Arild Nesbakken and Oddmund Nordg{\aa}rd and Stephan Brackmann and Torleiv Ole Rognum and Ragnhild A. Lothe and Rolf I. Skotheim},
  journal={International journal of cancer},
  year={2012},
  volume={131 6},
  pages={1479-85}
}
An alternative transcript variant of SLC39A14, caused by pre-mRNA splicing, was recently suggested as a biomarker for colorectal cancer (CRC). In our study, we have validated the cancer-specific splicing pattern of the mutually exclusive exons 4A and 4B in altogether 244 colorectal tissue samples. Exon-specific quantitative RT-PCR analyses across 136 Stage I-IV CRC samples and 44 normal colonic mucosa samples showed complete cancer-specificity, as well as 94% sensitivity of SLC39A14-exon4B… CONTINUE READING