The exon-intron architecture of human chloride channel genes is not conserved.

Abstract

The human CLCN6 gene contains a 167 bp exon that is optionally included or excluded in ClC-6 mRNAs. The corresponding region (3.4 kbp) of the human CLCN7 gene has now been cloned and sequenced. A comparison of the human CLCN1, CLCN5, CLCN6 and CLCN7 genes indicates that there is no homologue of the optional CLCN6 exon in the CLCN1, CLCN5 or CLCN7 genes… (More)

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