The exogenous NADH dehydrogenase of heart mitochondria is the key enzyme responsible for selective cardiotoxicity of anthracyclines.

@article{Nohl1998TheEN,
  title={The exogenous NADH dehydrogenase of heart mitochondria is the key enzyme responsible for selective cardiotoxicity of anthracyclines.},
  author={Herman Nohl and Lars Gille and Katrin Staniek},
  journal={Zeitschrift fur Naturforschung. C, Journal of biosciences},
  year={1998},
  volume={53 3-4},
  pages={
          279-85
        }
}
The molecular mechanism of the anthracycline-dependent development of cardiotoxicity is still far from being clear. However, it is generally accepted, that mitochondria play a significant role in triggering this organ specific injury. The results presented in this study demonstrate that, in contrast to liver mitochondria, isolated heart mitochondria shuttle single electrons to adriamycin, giving rise to oxygen radical formation via autoxidation of adriamycin semiquinones. This one electron… CONTINUE READING

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