The exocyst localizes to the primary cilium in MDCK cells.

  title={The exocyst localizes to the primary cilium in MDCK cells.},
  author={Katherine K Rogers and Patricia D. Wilson and Richard W Snyder and Xiaoyu Zhang and Wei Guo and Christopher R. Burrow and Joshua H. Lipschutz},
  journal={Biochemical and biophysical research communications},
  volume={319 1},
Primary cilia play a role in the maintenance of tubular epithelial differentiation and ciliary dysfunction can result in abnormal cyst formation, such as occurs in autosomal dominant polycystic kidney disease (ADPKD). We previously showed that the exocyst, an eight-protein complex involved in the biogenesis of polarity from yeast to mammals, is centrally involved in cyst formation [Mol. Biol. Cell. 11 (2000) 4259]. Here we show that the exocyst complex localizes to the primary cilium in Madin… CONTINUE READING


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