The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin

@article{Inoue2003TheEC,
  title={The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin},
  author={Mayumi Inoue and Louise Chang and Joseph B. Hwang and S Chiang and Alan R. Saltiel},
  journal={Nature},
  year={2003},
  volume={422},
  pages={629-633}
}
Insulin stimulates glucose transport by promoting exocytosis of the glucose transporter Glut4 (refs 1, 2). The dynamic processes involved in the trafficking of Glut4-containing vesicles, and in their targeting, docking and fusion at the plasma membrane, as well as the signalling processes that govern these events, are not well understood. We recently described tyrosine-phosphorylation events restricted to subdomains of the plasma membrane that result in activation of the G protein TC10 (refs 3… CONTINUE READING
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