The exocyst and regulatory GTPases in urinary exosomes

@inproceedings{ChaconHeszele2014TheEA,
  title={The exocyst and regulatory GTPases in urinary exosomes},
  author={Maria F Chacon-Heszele and Soo Young Choi and Xiaofeng Zuo and Jeong‐In Baek and Christopher W Ward and Joshua H Lipschutz},
  booktitle={Physiological reports},
  year={2014}
}
Cilia, organelles that function as cellular antennae, are central to the pathogenesis of "ciliopathies", including various forms of polycystic kidney disease (PKD). To date, however, the molecular mechanisms controlling ciliogenesis and ciliary function remain incompletely understood. A recently proposed model of cell-cell communication, called "urocrine signaling", hypothesizes that a subset of membrane bound vesicles that are secreted into the urinary stream (termed exosome-like vesicles, or… CONTINUE READING

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