The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria.

@article{ElFakhri1982TheEO,
  title={The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria.},
  author={Mustafa M El-Fakhri and Bruce Middleton},
  journal={Biochimica et biophysica acta},
  year={1982},
  volume={713 2},
  pages={270-9}
}
L-3-Hydroxyacyl-CoA dehydrogenase was measured in mammalian tissues with long-chain (C16) and short-chain (C4) 3-ketoacyl-CoA substrates. The majority of the activity was mitochondrial. Activity with C16 substrate was enriched in the inner membrane fraction while the matrix showed enrichment of activity with C4 substrate. Gel-filtration in the presence of nonionic and ionic detergents separated two peaks of activity with C16 substrate from liver, heart, kidney and brown adipose tissue… CONTINUE READING

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